Current Issue : July - September Volume : 2018 Issue Number : 3 Articles : 6 Articles
Introduction. Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis.\nSoluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to\ninvestigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods. Fiftyfive\npatients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of\nstages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level\nwas measured using commercial ELISA kit. Results.Themonocyte count of subjects in groups IVB and IVC was significantly higher\ncompared to group I-IVA (707/...
The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing\nmyocardial infarction however they also have a role in chronic disease management. This pilot\nstudy assessed the relationship of hs-troponins with echocardiographic markers of left ventricular\nhypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography\n(CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited.\nHs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide\n(NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy\n(LVHEcho) and left atrial enlargement (LAEEcho) on echocardiography. 78 subjects who underwent\nechocardiography were included in this study. C-statistics (95% confidence interval) of the\nfour biomarkers for predicting LVHEcho were 0.84 (0.72ââ?¬â??0.92), 0.84 (0.73ââ?¬â??0.92), 0.75 (0.63ââ?¬â??0.85) and\n0.62 (0.49ââ?¬â??0.74); for LAEEcho 0.74 (0.6ââ?¬â??0.85), 0.78 (0.66ââ?¬â??0.88), 0.55 (0.42ââ?¬â??0.67) and 0.68 (0.62ââ?¬â??0.85);\nand composite SHD 0.79 (0.66ââ?¬â??0.88), 0.87 (0.75ââ?¬â??0.94), 0.62 (0.49ââ?¬â??0.73) and 0.74 (0.62ââ?¬â??0.84) respectively.\nOptimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively.\nThese results advocate the potential role of hs-troponins as screening tools for structural heart disease\nwith theranostic implications....
Background. There is little published literature regarding the impact of age on outcomes amongst hospitalized HHT (hereditary\nhemorrhagic telangiectasia) patients. Methods. The Nationwide Inpatient Sample (NIS) was used to obtain data on all hospital\ndischarges occurring in HHT patients from 2000 to 2012. The association between admission age and HHT-related complications\nand outcomes were studied. Results. 10293 hospitalizations in HHT patients from 2000 to 2012 were included. Patients > 50\naccounted for 77% of all admissions with 30% of admissions occurring in the 51ââ?¬â??65 age group. Bleeding related complications\nwere the most frequent (62.7%, ...
Introduction. Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute\nmyeloblastic leukemia (AML). Case Report. A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and\ndiarrhea. She had a maculopapular skin rash, hepatosplenomegaly, retroperitoneal adenopathies, pancytopenia, 6% blast cells\n(BC) and 20% MC in the peripheral blood, elevated lactate dehydrogenase, cholestasis, hypoalbuminemia, hypogammaglobulinemia,\nand increased serum tryptase (184 �¼g/L). The bone marrow (BM) smears showed 24% myeloblasts, 17% promyelocytes,\nand 16% abnormal toluidine blue positive MC, and flow cytometry revealed 12% myeloid BC, 34% aberrant promyelocytes,\na maturation blockage at the myeloblast/promyelocyte level, and 16...
The growth in percutaneous transluminal devices has enabled operators to tackle more complex, native, and post-bypass surgery\nanatomy. However, complications such as coronary artery dissection, coronary perforation, retrograde aortic dissection, arrhythmias,\nand acute coronary syndrome still occur with resulting mortality rates of up to 4.2% in complex interventions.\nPerforation of the circumflex artery is of particular interest in view of its position and relation to the surrounding cardiac\nstructures. This is a site of potential fluid collection, and as the left atrium is fixed to the parietal pericardium at the entry of the\npulmonary veins, fluid in the oblique sinus can accumulate enough pressure to compress the left atrium and the coronary sinus.\nWe present a case of left circumflex artery perforation which demonstrates the physiologic complications of coronary sinus and\nleft atrial compression and the resultant functional mitral stenosis...
One of the most recently proposed candidates as a potential trigger for cardiovascular\ndiseases is trimethylamine-N-oxide (TMAO). Possible direct effects of TMAO on myocardial\ntissue, independent of vascular damage, have been only partially explored so far. In the\npresent study, we assessed the detrimental direct effects of TMAO on cardiomyocyte contractility\nand intracellular calcium dynamics, and the ability of urolithin B-glucuronide (Uro B-gluc) in\ncounteracting TMAO-induced cell damage. Cell mechanics and calcium transients were measured,\nand ultrastructural analysis was performed in ventricular cardiomyocytes isolated from the heart\nof normal adult rats. Cells were either untreated, exposed to TMAO, or to TMAO and Uro\nB-gluc. TMAO exposure worsened cardiomyocyte mechanics and intracellular calcium handling,\nas documented by the decrease in the fraction of shortening (FS) and the maximal rate of\nshortening and re-lengthening, associated with reduced efficiency in the intracellular calcium removal.\nUltrastructurally, TMAO-treated cardiomyocytes also exhibited glycogen accumulation, a higher\nnumber of mitochondria and lipofuscin-like pigment deposition, suggesting an altered cellular\nenergetic metabolism and a higher rate of protein oxidative damage, respectively. Uro B-gluc led\nto a complete recovery of cellular contractility and calcium dynamics, and morphologically to\na reduced glycogen accumulation. We demonstrated for the first time a direct negative role of\nTMAO on cardiomyocyte functional properties and the ability of Uro B-gluc in counteracting these\ndetrimental effects....
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